Maintenance of time-restricted eating and high-intensity interval training in women with overweight/obesity 2 years after a randomized controlled trial

Haganes, Kamilla L, Hawley, John A, Lydersen, Stian and Moholdt, Trine (2025) Maintenance of time-restricted eating and high-intensity interval training in women with overweight/obesity 2 years after a randomized controlled trial. Scientific Reports, 15. 14520. ISSN 2045-2322

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Abstract

Time-restricted eating (TRE) and high-intensity interval training (HIIT) improve cardiometabolic health in individuals with overweight/obesity, with high adherence rates in supervised settings. Long-term maintenance of TRE and HIIT in real-world settings is unknown. In our previous TREHIIT trial, 131 women (body mass index (BMI) ≥ 27 kg/m2) were randomized to 7 weeks of TRE (eating window 10-h/day), HIIT (3 sessions/week), a combination (TREHIIT), or no intervention (CON). We investigated self-reported continuation of TRE and/or HIIT after 2 years. Fifty-nine participants (39.0 years (standard deviation (SD) 6.1), BMI 30.7 kg/m2 (SD 4.2)) attended the follow-up. Of those who completed the 7-week TRE or HIIT intervention, 46% maintained TRE and 45% continued HIIT for 2 years. There were no statistically significant (at p < .01) between-group differences in cardiometabolic outcomes, but non-significant lower body mass in HIIT (-4.2 kg, 95% confidence interval (CI), -7.7 to -0.7, p = .019) and visceral fat in TREHIIT (-18 cm2, CI, -33 to -4, p = .015) versus CON. After 2 years, HIIT and TREHIIT had ~ 4 kg lower fat mass and ~ 20 cm² lower visceral fat (both p < .001) compared with baseline. A short-term TRE and HIIT intervention may promote long-term lifestyle changes and health benefits. Future studies should collect objective adherence data to understand long-term maintenance of TRE and HIIT.