Blood-brain barrier permeable β-blockers association with Alzheimer's disease cerebrospinal fluid biomarkers levels in non-demented individuals

Buongiorno, Mariateresa ORCID: https://orcid.org/0000-0002-1745-5744, Sánchez-Benavides, Gonzalo, Marzal-Espí, Clara, Giraldo, Darly Milena, Krupinski, Jerzy ORCID: https://orcid.org/0000-0002-5136-8898, Cullell, Natalia, Grau-Rivera, Oriol, Suárez-Calvet, Marc, Gispert, Juan Domingo and de la Sierra, Alex (2024) Blood-brain barrier permeable β-blockers association with Alzheimer's disease cerebrospinal fluid biomarkers levels in non-demented individuals. Journal of Alzheimer’s Disease, 102 (4). pp. 975-980. ISSN 1875-8908

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Official URL: https://doi.org/10.1177/13872877241293812

Abstract

β-blockers that easily cross the blood-brain barrier (BBB) seem to diminish the risk of Alzheimer's disease (AD), hypothetically facilitating waste clearance. However, their effect on AD pathophysiological markers is unknown. We compared cerebrospinal fluid (CSF) AD biomarker levels among non-demented individuals taking low, intermediate, or high BBB permeable β-blockers in two samples (ADNI: n = 216; EPAD: n = 79). We found that CSF amyloid-β levels were higher in individuals taking highly permeable β-blockers in the ADNI sample. This result was not replicated in EPAD, in which diminished levels of pTau181 and tTau were observed. These data suggest that β-blockers may impact AD pathophysiology.

Item Type:	Article (Article)
Peer-reviewed:	Yes
Date Deposited:	16 Jan 2025 08:42
Publisher:	SAGE Publications
Additional Information:	This is an author-produced version of the published paper. Uploaded in accordance with the University’s Research Publications Policy.
Divisions:	Faculties > Science and Engineering > Department of Life Science
Data Access Statement:	The data used in reparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu), which is available upon request, and from the EPAD LCS data set V.IMI (doi:10.34688/epadlcs_v.imi_20.10.30). EPAD LCS data is publicly available upon request to the EPAD data access committee.
URI:	https://e-space.mmu.ac.uk/id/eprint/637430
DOI:	https://doi.org/10.1177/13872877241293812
ISSN	1875-8908

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