Influence of Ethnicity and Deprivation on Occurrence of Paget’s Disease in Greater Manchester, UK

Heald, A H ORCID: https://orcid.org/0000-0002-9537-4050, Lu, W, Williams, R, McCay, K, Maharani, A, Cook, M J and O’Neill, T W (2024) Influence of Ethnicity and Deprivation on Occurrence of Paget’s Disease in Greater Manchester, UK. Calcified Tissue International, 115 (5). pp. 542-551. ISSN 0171-967X

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Abstract

There is important variation in the occurrence of Paget’s disease in different regions and populations. There are though few data concerning the occurrence of clinically diagnosed disease in black and ethnic minority groups in the United Kingdom (UK). We undertook an anonymised search using an integrated primary and secondary care-based database in Greater Manchester, covering a population of over 3 million people. We looked also among those with a first positive COVID test, the influence of Paget’s disease on subsequent admission to hospital within 28 days. Within our database, there were 534,571 people aged 60 years and over alive on 1 January 2020. The majority were white (84%) with 4.7% identifying as Asian or Asian British, and 1.27% Black or Black British. There were 931 with clinically diagnosed Paget’s disease. Overall prevalence in the greater Manchester area was 0.174%. Prevalence was higher in men than women (0.195 vs 0.155%). Compared to the prevalence of Paget’s in whites (0.179%) the prevalence was lower among those identifying as Asian or Asian British (0.048%) and higher among those identifying as Black or Black British (0.344%). Prevalence increased with increasing deprivation. Clinically diagnosed Paget’s disease is uncommon affecting 0.174% of men and women aged 60 or more years. Within Greater Manchester, it was more common in those identifying as Black or Black British and less common in those identifying as Asian or Asian British.