Electroanalytical overview: the sensing of the mycophenolate mofetil and mycophenolic acid

Crapnell, Robert D ORCID: https://orcid.org/0000-0002-8701-3933 and Banks, Craig E ORCID: https://orcid.org/0000-0002-0756-9764 (2024) Electroanalytical overview: the sensing of the mycophenolate mofetil and mycophenolic acid. Analytical Methods, 16 (41). pp. 6954-6963. ISSN 1759-9679

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Abstract

In this review, we explore the electroanalytical determination of mycophenolate mofetil and mycophenolic acid. Mycophenolate mofetil is a prodrug of mycophenolic acid, which is an immunosuppressive agent used to lower the body's natural immunity in patients who receive organ transplants as well as to treat autoimmune conditions. Laboratory based analytical instrumentation provide a routine methodology to measure mycophenolate mofetil and its metabolites, but there is scope to develop in-the-field analytical measurements that are comparable to those from laboratory equipment. Electroanalysis provides an opportunity to provide highly selective and sensitive outputs but are cost-efficient and can support on-site analysis. In this review, we provide an electroanalytical overview of the current research directed toward the measurement of mycophenolate mofetil and mycophenolic acid, offering insights to future research.