Anti-inflammatory agent

Ashworth, Jason ORCID: https://orcid.org/0000-0001-7045-7899 (2023) Anti-inflammatory agent. In: Modified Rice Bran Arabinoxylan: Therapeutic Applications in Cancer and Other Diseases. Springer, Singapore, pp. 41-51. ISBN 9789811957345 (hardcover); 9789811957352 (ebook)

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Abstract

There is accumulating evidence that rice bran extracts have profound effects on mediating inflammation, with the therapeutic potential of rice bran widely explored in several chronic inflammatory conditions including asthma, diabetes, obesity, dermatitis, arthritis, liver injury, neuroinflammation, and cancer. However, rice bran extracts are often poorly characterised, making it difficult to ascertain which constituents of the extract are contributing to the observed antiinflammatory properties. Despite this drawback, rice bran arabinoxylans (AXs), or AX-derived compounds such as ferulic acid and feruloylated oligosaccharides, have been identified as principal anti-inflammatory agents in rice bran extracts. Moreover, AX-induced patterns of anti-inflammatory effects involving changes in transcription factor regulation, gene transcription, enzyme activity, or inflammatory cytokine/mediator secretion are beginning to emerge in the research literature. Given the body of published research primarily utilises modified rice bran AX, commonly known as Biobran or MGN-3, there is ample scope to explore a wider range of non-modified rice bran AXs as anti-inflammatory agents in future work. Exploiting the emerging anti-inflammatory properties of rice bran AXs to develop potential treatments or prophylactic therapies for inflammatory diseases is an exciting prospect that warrants further investigation.