A randomised controlled trial exploring the effects of different beverages consumed alongside a nitrate-rich meal on systemic blood pressure

McDonagh, Sinead Tj, Wylie, Lee J, Morgan, Paul T, Vanhatalo, Anni and Jones, Andrew M (2018) A randomised controlled trial exploring the effects of different beverages consumed alongside a nitrate-rich meal on systemic blood pressure. Nutrition and Health, 24 (3). pp. 183-192. ISSN 0260-1060

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Official URL: https://doi.org/10.1177/0260106018790428

Abstract

BACKGROUND: Ingestion of nitrate (NO3-)-containing vegetables, alcohol and polyphenols, separately, can reduce blood pressure (BP). However, the pharmacokinetic response to the combined ingestion of NO3- and polyphenol-rich or low polyphenol alcoholic beverages is unknown. AIM: The aim of this study was to investigate how the consumption of low and high polyphenolic alcoholic beverages combined with a NO3--rich meal can influence NO3- metabolism and systemic BP. METHODS: In a randomised, crossover trial, 12 normotensive males (age 25 ± 5 years) ingested an acute dose of NO3- (∼6.05 mmol) in the form of a green leafy salad, in combination with either a polyphenol-rich red wine (NIT-RW), a low polyphenol alcoholic beverage (vodka; NIT-A) or water (NIT-CON). Participants also consumed a low NO3- salad and water as a control (CON; ∼0.69 mmol NO3-). BP and plasma, salivary and urinary [NO3-] and nitrite ([NO2-]) were determined before and up to 5 h post ingestion. RESULTS: Each NO3--rich condition elevated nitric oxide (NO) biomarkers when compared with CON ( P < 0.05). The peak rise in plasma [NO2-] occurred 1 h after NIT-RW (292 ± 210 nM) and 2 h after NIT-A (318 ± 186 nM) and NIT-CON (367 ± 179 nM). Systolic BP was reduced 2 h post consumption of NIT-RW (-4 mmHg), NIT-A (-3 mmHg) and NIT-CON (-2 mmHg) compared with CON ( P < 0.05). Diastolic BP and mean arterial pressure were also lower in NIT-RW and NIT-A compared with NIT-CON ( P < 0.05). CONCLUSIONS:: A NO3--rich meal, consumed with or without an alcoholic beverage, increases plasma [NO2-] and lowers systemic BP for 2-3 h post ingestion.

Item Type:	Article (Article)
Peer-reviewed:	Yes
Date Deposited:	18 Jan 2024 13:40
Publisher:	SAGE Publications
Additional Information:	Due to copyright reasons, we are unable to provide full-text access through this repository.
Divisions:	Faculties > Science and Engineering
Subject terms:	Humans, Vegetables, Nitrates, Nitrites, Nitric Oxide, Nitrogen Oxides, Ethanol, Cross-Over Studies, Blood Pressure, Reference Values, Beverages, Alcoholic Beverages, Wine, Adult, Female, Male, Young Adult, Polyphenols, Meals, Alcohol, Mediterranean diet, blood pressure, dietary nitrate, nitric oxide, pharmacokinetics, red wine, Adult, Alcoholic Beverages, Beverages, Blood Pressure, Cross-Over Studies, Ethanol, Female, Humans, Male, Meals, Nitrates, Nitric Oxide, Nitrites, Nitrogen Oxides, Polyphenols, Reference Values, Vegetables, Wine, Young Adult, Humans, Vegetables, Nitrates, Nitrites, Nitric Oxide, Nitrogen Oxides, Ethanol, Cross-Over Studies, Blood Pressure, Reference Values, Beverages, Alcoholic Beverages, Wine, Adult, Female, Male, Young Adult, Polyphenols, Meals, Alcohol, Mediterranean diet, blood pressure, dietary nitrate, nitric oxide, pharmacokinetics, red wine, Adult, Alcoholic Beverages, Beverages, Blood Pressure, Cross-Over Studies, Ethanol, Female, Humans, Male, Meals, Nitrates, Nitric Oxide, Nitrites, Nitrogen Oxides, Polyphenols, Reference Values, Vegetables, Wine, Young Adult, Nutrition & Dietetics, Nutrition & Dietetics
URI:	https://e-space.mmu.ac.uk/id/eprint/633292
DOI:	https://doi.org/10.1177/0260106018790428
ISSN	0260-1060

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