Electroanalytical Overview: The Determination of Levodopa (L-DOPA)

Crapnell, Robert ORCID: https://orcid.org/0000-0002-8701-3933 and Banks, Craig E ORCID: https://orcid.org/0000-0002-0756-9764 (2023) Electroanalytical Overview: The Determination of Levodopa (L-DOPA). ACS Measurement Science Au, 3 (2). pp. 84-97. ISSN 2694-250X

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Abstract

L-DOPA (levodopa) is a therapeutic agent which is the most effective medication for treating Parkinson’s disease, but it needs dose optimization, and therefore its analytical determination is required. Laboratory analytical instruments can be routinely used to measure L-DOPA but are not always available in clinical settings and traditional research laboratories, and they also have slow result delivery times and high costs. The use of electroanalytical sensing overcomes these problems providing a highly sensitivity, low-cost, and readily portable solution. Consequently, we overview the electroanalytical determination of L-DOPA reported throughout the literature summarizing the endeavors toward sensing L-DOPA, and we offer insights into future research opportunities.