Evaluating the Possibility of Translating Technological Advances in Non-Invasive Continuous Lactate Monitoring into Critical Care

Crapnell, Robert D ORCID: https://orcid.org/0000-0002-8701-3933, Tridente, Ascanio, Banks, Craig E ORCID: https://orcid.org/0000-0002-0756-9764 and Dempsey-Hibbert, Nina C (2021) Evaluating the Possibility of Translating Technological Advances in Non-Invasive Continuous Lactate Monitoring into Critical Care. Sensors, 21 (3). p. 879. ISSN 1424-8220

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Official URL: https://www.mdpi.com/1424-8220/21/3/879

Abstract

Lactate is widely measured in critically ill patients as a robust indicator of patient deterioration and response to treatment. Plasma concentrations represent a balance between lactate production and clearance. Analysis has typically been performed with the aim of detecting tissue hypoxia. However, there is a diverse range of processes unrelated to increased anaerobic metabolism that result in the accumulation of lactate, complicating clinical interpretation. Further, lactate levels can change rapidly over short spaces of time, and even subtle changes can reflect a profound change in the patient’s condition. Hence, there is a significant need for frequent lactate monitoring in critical care. Lactate monitoring is commonplace in sports performance monitoring, given the elevation of lactate during anaerobic exercise. The desire to continuously monitor lactate in athletes has led to the development of various technological approaches for non-invasive, continuous lactate measurements. This review aims firstly to reflect on the potential benefits of non-invasive continuous monitoring technology within the critical care setting. Secondly, we review the current devices used to measure lactate non-invasively outside of this setting and consider the challenges that must be overcome to allow for the translation of this technology into intensive care medicine. This review will be of interest to those developing continuous monitoring sensors, opening up a new field of research.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	02 Feb 2023 09:10
Publisher:	MDPI AG
Additional Information:	Open access article published by MDPI, copyright The Authors.
Divisions:	Faculties > Science and Engineering Research Centres > Advanced Materials and Surface Engineering Research Centres > Centre for Bioscience
Subject terms:	Science & Technology, Physical Sciences, Technology, Chemistry, Analytical, Engineering, Electrical & Electronic, Instruments & Instrumentation, Chemistry, Engineering, lactate, critical care, hyperlactataemia, sensors, non-invasive, continuous monitoring, POINT-OF-CARE, MOLECULARLY IMPRINTED POLYMERS, WEARABLE SENSOR SYSTEM, BLOOD LACTATE, ILL PATIENTS, ELECTROCHEMICAL BIOSENSOR, AMPEROMETRIC BIOSENSOR, HOSPITAL MORTALITY, SEVERE SEPSIS, BIOFUEL-CELL, Humans, Critical Illness, Lactic Acid, Monitoring, Physiologic, Critical Care, Technology, continuous monitoring, critical care, hyperlactataemia, lactate, non-invasive, sensors, Critical Care, Critical Illness, Humans, Lactic Acid, Monitoring, Physiologic, Technology, 0301 Analytical Chemistry, 0502 Environmental Science and Management, 0602 Ecology, 0805 Distributed Computing, 0906 Electrical and Electronic Engineering, Analytical Chemistry
Data Access Statement:	Not applicable.
Report number:	3
URI:	https://e-space.mmu.ac.uk/id/eprint/629068
DOI:	https://doi.org/10.3390/s21030879
ISSN	1424-8220