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    Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions

    Basson, Ashley and McLaughlin, Mark Gerard (2020) Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions. The Journal of Organic Chemistry, 85 (8). pp. 5615-5628. ISSN 0022-3263

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    Abstract

    Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readi-ly available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 27 Mar 2020 08:56
    Publisher: American Chemical Society (ACS)
    Additional Information: “This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © American Chemical Society and the Division of Chemical Education, Inc., after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see https://pubs.acs.org/doi/10.1021/acs.joc.0c00482
    Divisions: Faculties > Science and Engineering
    Subject terms: Organic Chemistry, 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry
    Report number: acs.joc.0c00482
    URI: https://e-space.mmu.ac.uk/id/eprint/625429
    DOI: https://doi.org/10.1021/acs.joc.0c00482
    ISSN 0022-3263
    e-ISSN 1520-6904

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