e-space
Manchester Metropolitan University's Research Repository

    A history of opioid exposure in females increases the risk of metabolic disorders in their future male offspring

    Toorie, AM, Vassoler, FM, Qu, F, Schonhoff, CM, Bradburn, S, Murgatroyd, CA ORCID logoORCID: https://orcid.org/0000-0002-6885-7794, Slonim, DK and Byrnes, EM (2021) A history of opioid exposure in females increases the risk of metabolic disorders in their future male offspring. Addiction Biology, 26 (1). e12856. ISSN 1355-6215

    [img]
    Preview
    Accepted Version
    Download (2MB) | Preview

    Abstract

    © 2019 Society for the Study of Addiction Worldwide consumption of opioids remains at historic levels. Preclinical studies report intergenerational effects on the endogenous opioid system of future progeny following preconception morphine exposure. Given the role of endogenous opioids in energy homeostasis, such effects could impact metabolism in the next generation. Thus, we examined diet-induced modifications in F1 male progeny of morphine-exposed female rats (MORF1). When fed a high fat-sugar diet (FSD) for 6 weeks, MORF1 males display features of emerging metabolic syndrome; they consume more food, gain more weight, and develop fasting-induced hyperglycemia and hyperinsulinemia. In the hypothalamus, proteins involved in energy homeostasis are modified and RNA sequencing revealed down-regulation of genes associated with neuronal plasticity, coupled with up-regulation of genes associated with immune, inflammatory, and metabolic processes that are specific to FSD-maintained MORF1 males. Thus, limited preconception morphine exposure in female rats increases the risk of metabolic syndrome/type 2 diabetes in the next generation.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    416Downloads
    6 month trend
    228Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record