Functionalisation of Isoindolinones via a Calcium Catalysed Hosomi-Sakurai Allylation

Basson, Ashley James and McLaughlin, Mark G (2019) Functionalisation of Isoindolinones via a Calcium Catalysed Hosomi-Sakurai Allylation. Chemical Communications, 55 (57). pp. 8317-8320. ISSN 1359-7345

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Official URL: https://doi.org/10.1039/C9CC02450F

Abstract

A rapid and functionally tolerant calcium catalysed Hosomi-Sakurai reaction has been realised. Employing 1 mol% calcium, allylated isoindolinones can be synthesised in high yields and the reaction is shown to be tolerant to a range of medicinally relevant functional groups including heterocycles. The synthetic utility of the reaction has been shown, and a plausible reaction mechanism is provided.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	25 Jun 2019 11:18
Publisher:	Royal Society of Chemistry
Additional Information:	This is an Open Access article published in ChemComm, published by and copyright Royal Society of Chemistry.
Divisions:	Faculties > Science and Engineering
Subject terms:	Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, ASYMMETRIC-SYNTHESIS, EFFICIENT SYNTHESIS, CYCLIZATION, RUCL2(=CHR)(PR(3))(2), ISOINDOLIN-1-ONES, LACTAMS, 03 Chemical Sciences, Organic Chemistry
URI:	https://e-space.mmu.ac.uk/id/eprint/623167
DOI:	https://doi.org/10.1039/c9cc02450f
ISSN	1359-7345
e-ISSN	1364-548X

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