e-space
Manchester Metropolitan University's Research Repository

    Catalytic enantioselective addition of organozirconium reagents to aldehydes

    Solà, R, Veguillas, M, González-Soria, MJ, Carter, N, Fernández-Ibáñez, MA and Maciá, B (2018) Catalytic enantioselective addition of organozirconium reagents to aldehydes. Molecules, 23 (4). ISSN 1420-3049

    [img]
    Preview

    Available under License Creative Commons Attribution.

    Download (3MB) | Preview

    Abstract

    © 2018 by the authors. A catalytic enantioselective addition reaction of alkylzirconium species to aromatic aldehydes is reported. The reaction, facilitated by a chiral nonracemic diol ligand complex with Ti(OiPr)4, proceeds under mild and convenient conditions, and no premade organometallic reagents are required since the alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The methodology is compatible with functionalized nucleophiles and a broad range of aromatic aldehydes.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    309Downloads
    6 month trend
    304Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record