Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters

Betlem, K ORCID: https://orcid.org/0000-0002-5210-5619, Down, MP ORCID: https://orcid.org/0000-0001-6154-4974, Foster, CW ORCID: https://orcid.org/0000-0002-5487-2803, Akthar, S, Eersels, K, van Grinsven, B, Cleij, T, Banks, CE ORCID: https://orcid.org/0000-0002-0756-9764 and Peeters, M ORCID: https://orcid.org/0000-0002-0429-8073 (2018) Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters. MRS Advances, 3 (28). pp. 1569-1574. ISSN 2059-8521

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Abstract

We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.