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    Using 2H Labelling to Improve the NMR Detectability of Pyridine and its Derivatives by SABRE

    Norcott, P, Burns, MJ, Rayner, PJ, Mewis, Ryan and Duckett, SB (2017) Using 2H Labelling to Improve the NMR Detectability of Pyridine and its Derivatives by SABRE. Magnetic Resonance in Chemistry, 56 (7). pp. 663-671. ISSN 0749-1581

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    Abstract

    By introducing a range of 2 H labels into pyridine and the para-substituted agents methyl isonicotinate and isonicotinamide we significantly improve their NMR detectability in conjunction with the Signal Amplification by Reversible Exchange (SABRE) process. We describe how the rates of T1 relaxation for the remaining 1 H nuclei are increased and show how this leads to a concomitant increase in the level of 1 H and 13 C hyperpolarization that can ultimately be detected.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 04 Jan 2018 11:16
    Publisher: Wiley
    Additional Information: This is an Author Accepted Manuscript of a paper accepted for publication in Magnetic Resonance in Chemistry, published by and copyright Wiley.
    Divisions: Faculties > Science and Engineering
    Research Centres > Advanced Materials and Surface Engineering
    Subject terms: Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Chemistry, Physical, Spectroscopy, Chemistry, hyperpolarisation, NMR, parahydrogen, SABRE, NUCLEAR HYPERPOLARIZATION LEVELS, HYDROGEN INDUCED POLARIZATION, REVERSIBLE EXCHANGE, SIGNAL AMPLIFICATION, MAGNETIZATION, FIELD, PARAHYDROGEN, ORDER, COMPLEXES, LIFETIMES, NMR, SABRE, hyperpolarisation, parahydrogen, 0306 Physical Chemistry (Incl. Structural), 0304 Medicinal And Biomolecular Chemistry, Physical Chemistry
    URI: https://e-space.mmu.ac.uk/id/eprint/619704
    DOI: https://doi.org/10.1002/mrc.4703
    ISSN 0749-1581

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