Poly(para-Phenylene Ethynylene) (PPE)- and Poly(para-Phenylene Vinylene) (PPV)-Poly[(2-(Methacryloyloxy)Ethyl) Trimethylammonium Chloride] (PMETAC) Graft Copolymers Exhibit Selective Antimicrobial Activity

Damavandi, M, Pilkington, L, Whitehead, KA ORCID: https://orcid.org/0000-0001-6001-6686, Wilson-Nieuwenhuis, J, McBrearty, J, Dempsey-Hibbert, N, Travas-Sejdic, J and Barker, D (2018) Poly(para-Phenylene Ethynylene) (PPE)- and Poly(para-Phenylene Vinylene) (PPV)-Poly[(2-(Methacryloyloxy)Ethyl) Trimethylammonium Chloride] (PMETAC) Graft Copolymers Exhibit Selective Antimicrobial Activity. European Polymer Journal, 98. pp. 368-374. ISSN 0014-3057

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Abstract

Antimicrobial resistance is becoming a global health concern; as such, the need for new effective treatments and preventive measures is increasing. Poly(para-phenylene ethynylene) (PPE)- and poly(para-phenylene vinylene) (PPV)-poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) graft copolymers were tested against a range of clinically and industrially relevant bacteria and results showed many of these conjugated polyelectrolytes (CPE’s) to be active. Of all of the compounds tested, PPE-g-PMETAC (low molecular weight, LMW) had greatest antimicrobial activity, especially against Enterococcus faecium, Methicillin resistant Staphylococcus aureus (MRSA), Escherichia coli and Acinetobacter baumannii.

Item Type:	Article (Article)
Peer-reviewed:	Yes
Date Deposited:	27 Nov 2017 10:25
Publisher:	Elsevier
Additional Information:	This is an Author Accepted Manuscript of a paper accepted for publication in European Polymer Journal, published by and copyright Elsevier.
Divisions:	Faculties > Science and Engineering
Subject terms:	Science & Technology, Physical Sciences, Polymer Science, PPE, PPV, Graft copolymer, ARGET ATRP, Anti-microbial, TRANSFER RADICAL POLYMERIZATION, CONJUGATED POLYELECTROLYTES, ANTIBIOTIC-RESISTANCE, KLEBSIELLA-PNEUMONIAE, BACTERIA, POLYMERS, NANOPARTICLES, OLIGOMERS, POLY(P-PHENYLENEETHYNYLENE), PHOTOLUMINESCENCE, 0303 Macromolecular And Materials Chemistry, 0904 Chemical Engineering, 0912 Materials Engineering, Polymers
URI:	https://e-space.mmu.ac.uk/id/eprint/619481
DOI:	https://doi.org/10.1016/j.eurpolymj.2017.11.044
ISSN	0014-3057

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