Community-acquired methicillin-resistant staphylococcus aureus carrying panton-valentine leukocidin genes: Worldwide emergence

Vandenesch, F, Naimi, T, Enright, MC, Lina, G, Nimmo, GR, Heffernan, H, Liassine, N, Bes, M, Greenland, T, Reverdy, ME and Etienne, J (2003) Community-acquired methicillin-resistant staphylococcus aureus carrying panton-valentine leukocidin genes: Worldwide emergence. Emerging Infectious Diseases, 9 (8). pp. 978-984. ISSN 1080-6040

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Abstract

Infections caused by community-acquired (CA)-methicillin-resistant Staphylococcus aureus (MRSA) have been reported worldwide. We assessed whether any common genetic markers existed among 117 CA-MRSA isolates from the United States, France, Switzerland, Australia, New Zealand, and Western Samoa by performing polymerase chain reaction for 24 virulence factors and the methicillin-resistance determinant. The genetic background of the strain was analyzed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). The CA-MRSA strains shared a type IV SCCmec cassette and the Panton-Valentine leukocidin locus, whereas the distribution of the other toxin g enes was quite specific to the strains from each continent. PFGE and MLST analysis indicated distinct genetic backgrounds associated with each geographic origin, although predominantly restricted to the agr3 background. Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	18 Oct 2017 13:18
Publisher:	Centers for Disease Control and Prevention
Additional Information:	This is an Open Access article published in Emerging Infectious Diseases, published by Centers for Disease Control and Prevention.
Divisions:	Faculties > Science and Engineering Research Centres > Centre for Bioscience
Subject terms:	Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, IMMUNOLOGY, INFECTIOUS DISEASES, GEL-ELECTROPHORESIS, INFECTIONS, PNEUMONIA, CLONES, IDENTIFICATION, GENTAMICIN, AUSTRALIA, MRSA, Humans, Staphylococcus aureus, Communicable Diseases, Emerging, Community-Acquired Infections, Bacterial Toxins, Leukocidins, Exotoxins, Electrophoresis, Gel, Pulsed-Field, Microbial Sensitivity Tests, Methicillin Resistance, Bacterial Toxins, Communicable Diseases, Emerging, Community-Acquired Infections, Electrophoresis, Gel, Pulsed-Field, Exotoxins, Humans, Leukocidins, Methicillin Resistance, Microbial Sensitivity Tests, Staphylococcus aureus, 1108 Medical Microbiology, 1117 Public Health And Health Services, 1103 Clinical Sciences, Microbiology
URI:	https://e-space.mmu.ac.uk/id/eprint/619307
ISSN	1080-6040

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