Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes

Veguillas, M, Solà, R, Fernández-Ibañez, M and Maciá, B (2016) Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes. Tetrahedron Asymmetry, 27 (14-15). pp. 643-648. ISSN 0957-4166

Preview

Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (750kB) | Preview

Official URL: http://www.journals.elsevier.com/tetrahedron-asymm...

Abstract

© 2016 Elsevier Ltd An efficient catalyst for the enantioselective synthesis of chiral methyl carbinols from aldehydes is presented. The system uses methyltriisopropoxytitanium as a nucleophile and a readily available binaphthyl derivative as a chiral ligand. The enantioselective methylation of both aromatic and aliphatic aldehydes proceeds with good yields and high enantioselectivities under mild conditions.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	11 Apr 2017 08:02
Publisher:	Elsevier
Additional Information:	This is an Author Accepted Manuscript of a paper accepted for publication in Tetrahedron Asymmetry, published by and copyright Elsevier.
Divisions:	Faculties > Science and Engineering
Subject terms:	0305 Organic Chemistry, Organic Chemistry
URI:	https://e-space.mmu.ac.uk/id/eprint/618287
DOI:	https://doi.org/10.1016/j.tetasy.2016.06.001
ISSN	0957-4166

Impact and Reach

Statistics

DownloadsShow export options

Activity Overview

6 month trend

270Downloads

6 month trend

321Hits

Additional statistics for this dataset are available via IRStats2.

Altmetric

Repository staff only

Edit record