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    Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes

    Veguillas, M, Solà, R, Fernández-Ibañez, M and Maciá, B (2016) Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes. Tetrahedron Asymmetry, 27 (14-15). pp. 643-648. ISSN 0957-4166

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    Abstract

    © 2016 Elsevier Ltd An efficient catalyst for the enantioselective synthesis of chiral methyl carbinols from aldehydes is presented. The system uses methyltriisopropoxytitanium as a nucleophile and a readily available binaphthyl derivative as a chiral ligand. The enantioselective methylation of both aromatic and aliphatic aldehydes proceeds with good yields and high enantioselectivities under mild conditions.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 11 Apr 2017 08:02
    Publisher: Elsevier
    Additional Information: This is an Author Accepted Manuscript of a paper accepted for publication in Tetrahedron Asymmetry, published by and copyright Elsevier.
    Divisions: Faculties > Science and Engineering
    Research Centres > Advanced Materials and Surface Engineering
    Subject terms: 0305 Organic Chemistry, Organic Chemistry
    URI: https://e-space.mmu.ac.uk/id/eprint/618287
    DOI: https://doi.org/10.1016/j.tetasy.2016.06.001
    ISSN 0957-4166

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