Dibenzoyl-methane derivatives as a potential and exciting new therapy for the treatment of childhood bone cancer

Almelah, E, Smith, DPT, McGown, A, Aziz, A, Potgieter, JH and Ragazzon, P (2016) Dibenzoyl-methane derivatives as a potential and exciting new therapy for the treatment of childhood bone cancer. Anticancer Research, 36 (11). pp. 6043-6050. ISSN 0250-7005

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Abstract

Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We developed a novel molecule, 2′,4′-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteoblast cancer cell lines. Thionylation of 2′,4′-dihydroxydibenzoylmethane led to selective targeting of bone cancer cells, stopping their growth and leading to their death without affecting non-cancerous cells within the bone marrow or other non-malignant cells.