Epigenetic programming of neuroendocrine systems during early life

Murgatroyd, C (2013) Epigenetic programming of neuroendocrine systems during early life. Experimental Physiology, 99. ISSN 0958-0670

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Abstract

NArginine vasopressin plays a pivotal role in the control of long-lasting effects of early-life stress on the brain. We previously reported that maternal separation in mice persistently upregulates Avp gene expression associated with reduced DNA methylation of a region in the Avp enhancer. This early-life stress-responsive region serves as a binding site for the methyl-CpG binding protein 2, which in turn is controlled through neuronal activity. We also found that the ability of methyl-CpG binding protein 2 to regulate transcription of the Avp gene and induce DNA methylation occured through the recruitment of components of the epigenetic machinery. Understanding the sequential events involved in the epigenetic regulation of a gene should allow for targeted approaches aimed at reprogramming expression during development and possibly later life. © 2013 The Authors.