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    An Expedient Synthesis of Oxazepino and Oxazocino Quinazolines

    Jones, AM, Hensbergen, AW, Mills, VR and Collins, I (2015) An Expedient Synthesis of Oxazepino and Oxazocino Quinazolines. Tetrahedron Letters. ISSN 1873-3581 (Unpublished)

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    Abstract

    A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring closures afforded a collection of analogues. The scope of the reaction was explored in terms of cyclic and acyclic linkers, ring size and substitution pattern.

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