Improving the Hyperpolarization of P-31 Nuclei by Synthetic Design

Burns, MJ, Rayner, PJ, Green, GGR, Highton, LAR, Mewis, RE and Duckett, SB (2015) Improving the Hyperpolarization of P-31 Nuclei by Synthetic Design. JOURNAL OF PHYSICAL CHEMISTRY B, 119. ISSN 1520-6106

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Abstract

Traditional 31P NMR or MRI measurements suffer from low sensitivity relative to 1H detection and consequently require longer scan times. We show here that hyperpolarization of 31P nuclei through reversible interactions with parahydrogen can deliver substantial signal enhancements in a range of regioisomeric phosphonate esters containing a heteroaromatic motif which were synthesized in order to identify the optimum molecular scaffold for polarization transfer. A 3588-fold 31P signal enhancement (2.34% polarization) was returned for a partially deuterated pyridyl substituted phosphonate ester. This hyperpolarization level is sufficient to allow single scan 31P MR images of a phantom to be recorded at a 9.4 T observation field in seconds that have signal-to-noise ratios of up to 94.4 when the analyte concentration is 10 mM. In contrast, a 12 h 2048 scan measurement under standard conditions yields a signal-to-noise ratio of just 11.4. 31P-hyperpolarized images are also reported from a 7 T preclinical scanner