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    Catalytic Asymmetric Addition of Organolithium Reagents to Aldehydes

    Veguillas, M, Solà, R, Shaw, L and Maciá, B (2016) Catalytic Asymmetric Addition of Organolithium Reagents to Aldehydes. European Journal of Organic Chemistry, 2016 (9). pp. 1788-1794. ISSN 1434-193X

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    Abstract

    Copyright © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Herein we report an efficient catalytic system for the titanium-promoted enantioselective addition of organolithium reagents to aldehydes, based on chiral Ar-BINMOL ligands. Unprecedented yields and enantioselectivities are achieved in the alkylation reactions of aliphatic aldehydes. Remarkably, methyllithium can be added to a wide variety of aromatic and aliphatic aldehydes, providing versatile chiral methyl carbinol units in a simple one-pot procedure under mild conditions and in very short reaction times.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 12 Apr 2017 08:02
    Publisher: Wiley
    Additional Information: This is an Author Accepted Manuscript of a paper accepted for publication in European Journal of Organic Chemistry, published by and copyright Wiley.
    Divisions: Faculties > Science and Engineering
    Research Centres > Advanced Materials and Surface Engineering
    Subject terms: 0305 Organic Chemistry, 0304 Medicinal And Biomolecular Chemistry, Organic Chemistry
    URI: https://e-space.mmu.ac.uk/id/eprint/248
    DOI: https://doi.org/10.1002/ejoc.201600104
    ISSN 1434-193X

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