Cannabis use prior to first onset psychosis predicts spared neurocognition at 10-year follow-up

Stirling, John D., Lewis, Shôn, Hopkins, Richard S. and White, Colin (2005) Cannabis use prior to first onset psychosis predicts spared neurocognition at 10-year follow-up. Schizophrenia research, 75 (1). pp. 135-137. ISSN 0920-9964

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Abstract

A priori cannabis use was recorded at index admission for 112 participants in the Manchester first-episode psychosis cohort. 69 of the 100 surviving (mainly schizophrenia) patients were followed up 10–12 years later and assessed on a battery of clinical, behavioural and neurocognitive measures. Individuals who had not used cannabis before the first episode of illness were generally indistinguishable from cannabis users at follow-up, except that the latter group evidenced a marked 'sparing' of neurocognitive functions. These findings are briefly discussed in relation to other casual factors in psychosis.