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    Personalised nitinol stent for focal plaques: Design and evaluation

    He, R, Zhao, L, Silberschmidt, VV, Feng, J and Serracino-Inglott, F (2022) Personalised nitinol stent for focal plaques: Design and evaluation. Journal of Biomechanics, 130. p. 110873. ISSN 0021-9290

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    Abstract

    The purpose of this study is to develop personalised nitinol stents for arteries with one and two opposite focal plaques. Novel designs are evaluated through comparison with a commercial stent design, in terms of lumen gain and shape as well as stress levels in the media layer after stenting. Methods: Personalised stents are developed for arteries with one and two opposite focal plaques, based on medical imaging of patients and computer simulations. In silico analysis is then carried out for assessment of stent performance in the diseased arteries. Results: Personalised designs significantly increase the lumen gain, reduce the stresses in the media layer, and improve the lumen shape compared to the commercial nitinol stent. Conclusion: The personalised designs show outstanding performance compared to the commercial stent. Significance: This pilot study proves that personalised nitinol stents are able to deliver desirable treatment outcomes.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 30 Jun 2022 10:53
    Publisher: Elsevier
    Additional Information: This is an Open Access article published in Journal of Biomechanics by Elsevier.
    Divisions: Faculties > Science and Engineering
    Subject terms: Humans, Alloys, Pilot Projects, Prosthesis Design, Stents, Plaque, Atherosclerotic, Femoropopliteal artery, Finite element, Focal plaque, Nitinol stent, Personalised design, Alloys, Humans, Pilot Projects, Plaque, Atherosclerotic, Prosthesis Design, Stents, 0903 Biomedical Engineering, 0913 Mechanical Engineering, 1106 Human Movement and Sports Sciences, Biomedical Engineering
    Data Access Statement: Research data for this paper are available upon request to the project’s principal investigator Professor Liguo Zhao at Loughborough University, UK (email: L.Zhao@lboro.ac.uk).
    URI: https://e-space.mmu.ac.uk/id/eprint/630031
    DOI: https://doi.org/10.1016/j.jbiomech.2021.110873
    ISSN 0021-9290
    e-ISSN 1873-2380

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