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    Hyperpolarisation of Mirfentanil by SABRE in the Presence of Heroin

    Robertson, TBR, Gilbert, N, Sutcliffe, OB and Mewis, RE (2021) Hyperpolarisation of Mirfentanil by SABRE in the Presence of Heroin. ChemPhysChem, 22 (11). pp. 1059-1064. ISSN 1439-4235

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    Abstract

    Mirfentanil, a fentanyl derivative that is a μ-opioid partial agonist, is hyperpolarised via Signal Amplification By Reversible Exchange (SABRE), a para-hydrogen-based technique. [Ir(IMes)(COD)Cl] (IMes=1,3-bis(2,4,6-trimethylphenyl)imidazole-2-ylidene, COD=cyclooctadiene) was employed as the polarisation transfer catalyst. Following polarisation transfer at 6.5 mT, the pyrazine-protons were enhanced by 78-fold (polarisation, P=0.04 %). The complex [Ir(IMes)(H) (mirfentanil) (MeOH)] is proposed to form based on the observation of two hydrides at δ −22.9 (trans to mirfentanil) and −24.7 (trans to methanol). In a mixture of mirfentanil and heroin, the former could be detected using SABRE at concentrations less than 1 % w/w. At the lowest concentration analyzed, the amount of mirfentanil present was 0.18 mg (812 μM) and produced a signal enhancement of −867-fold (P=0.42 %). following polarisation transfer at 6.5 mT. 2 2 +

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 02 Jun 2021 07:42
    Publisher: Wiley
    Additional Information: This is an Author Accepted Manuscript of an article published in ChemPhysChem.
    Divisions: Faculties > Science and Engineering
    Subject terms: Science & Technology, Physical Sciences, Chemistry, Physical, Physics, Atomic, Molecular & Chemical, Chemistry, Physics, Mirfentanil, hyperpolarisation, SABRE, NMR, opioid, Mirfentanil, NMR, SABRE, hyperpolarisation, opioid, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, 0306 Physical Chemistry (incl. Structural), 0307 Theoretical and Computational Chemistry, Chemical Physics
    Report number: cphc.202100165
    URI: https://e-space.mmu.ac.uk/id/eprint/627569
    DOI: https://doi.org/10.1002/cphc.202100165
    ISSN 1439-4235
    e-ISSN 1439-7641

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