Enhanced reversible redox activity of hemin on cellulose microfiber integrated reduced graphene oxide for H2O2 biosensor applications

Palanisamy, S, Velusamy, V, Chen, SW, Yang, TCK, Balu, S and Banks, CE (2019) Enhanced reversible redox activity of hemin on cellulose microfiber integrated reduced graphene oxide for H2O2 biosensor applications. Carbohydrate Polymers, 204. pp. 152-160. ISSN 0144-8617

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Abstract

© 2018 Elsevier Ltd. In recent years, the carbohydrate polymers incorporated composite materials have shown significant interest in the bioanalytical chemistry due to their enhanced catalytic performances of various enzymes or mimics. This paper reports the fabrication of novel H2O2biosensor using a hemin immobilized reduced graphene oxide-cellulose microfiber composite (hemin/RGO-CMF). The RGO-CMF composite was prepared by the reduction of GO-CMF composite using vitamin C as a reducing agent. Various physio-chemical methods have applied for the characterization of RGO-CMF composite. Cyclic voltammetry results revealed that the hemin/RGO-CMF composite shows a better redox electrochemical behavior than hemin/RGO and hemin/GO-CMF. Under optimized conditions, the hemin/RGO-CMF composite exhibit a linear response to H2O2in the concentration range from 0.06 to 540.6 μM with the lower detection limit of 16 nM. The sensor also can able to detect the H2O2in commercial contact lens solution and milk samples with functional recovery, which authenticates the potential ability in practical sensors.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	08 Jan 2019 11:02
Publisher:	Elsevier
Additional Information:	This is an Author Accepted Manuscript of a paper accepted for publication in Carbohydrate Polymers, published by and copyright Elsevier.
Divisions:	Faculties > Science and Engineering Research Centres > Advanced Materials and Surface Engineering
Subject terms:	Science & Technology, Physical Sciences, Chemistry, Applied, Chemistry, Organic, Polymer Science, Chemistry, Peroxidase mimic, Hemin, Reduced graphene oxide, Cellulose microfibers, Redox electrochemistry, H2O2 biosensor, HYDROGEN-PEROXIDE, ELECTROCHEMICAL DETECTION, ELECTRODE SURFACE, NANOCOMPOSITE, REDUCTION, COMPOSITE, PROTEINS, GLUCOSE, ENZYMES, SYSTEMS, Cellulose microfibers, H(2)O(2) biosensor, Hemin, Peroxidase mimic, Redox electrochemistry, Reduced graphene oxide, 0305 Organic Chemistry, 0908 Food Sciences, 0303 Macromolecular and Materials Chemistry, Polymers
URI:	https://e-space.mmu.ac.uk/id/eprint/622102
DOI:	https://doi.org/10.1016/j.carbpol.2018.10.001
ISSN	0144-8617

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