e-space
Manchester Metropolitan University's Research Repository

    Arabinoxylans from rice bran and wheat immunomodulatory potentials: a review article

    Fadel, A, Plunkett, A, Li, W, Ranneh, Y, Gyamfi, V, Salmon, Y, Nyaranga, RR and Ashworth, J (2018) Arabinoxylans from rice bran and wheat immunomodulatory potentials: a review article. Nutrition & Food Science, 48 (1). pp. 97-110. ISSN 0034-6659

    [img]
    Preview
    Accepted Version
    Available under License In Copyright.

    Download (946kB) | Preview

    Abstract

    Purpose - The purpose of this review is to discuss recent research on arabinoxylans from rice bran and wheat by-products and their immunomodulatory potential. Also, a potential receptor for arabinoxylans is proposed in relation to arabinoxylan structure. Design/methodology/approach - This review summarises recent publications on arabinoxylans from rice bran and wheat, classification of arabinoxylans, a brief background on their methods of extraction, and their immunomodulatory potential as they induce proinflammatory responses in vitro, in vivo and humans. The mechanism of action by which arabinoxylans modulate immune activity has yet to be discovered, however, we have proposed a potential receptor for arabinoxylans in relation to arabinoxylans’ structure and molecular weight. Findings - The effects of arabinoxylans from rice bran and wheat on the immune response was found to cause a pro-inflammatory response in vitro, in vivo and humans. In addition, the immune response depends on their structure, the degree of branching and origin. Originality/Value - This review paper focuses on the effects of arabinoxylans from rice bran and wheat on immunomodulatory potential in vitro, in vivo and humans. A new mechanism of action has been proposed based on the literature and via the link between arabinoxylan and lipopolysaccharide structures, molecular weight and a proposed receptor, which might be activated via both molecules.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    867Downloads
    6 month trend
    429Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record