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    Poly(para-Phenylene Ethynylene) (PPE)- and Poly(para-Phenylene Vinylene) (PPV)-Poly[(2-(Methacryloyloxy)Ethyl) Trimethylammonium Chloride] (PMETAC) Graft Copolymers Exhibit Selective Antimicrobial Activity

    Damavandi, M, Pilkington, L, Whitehead, KA ORCID logoORCID: https://orcid.org/0000-0001-6001-6686, Wilson-Nieuwenhuis, J, McBrearty, J, Dempsey-Hibbert, N, Travas-Sejdic, J and Barker, D (2018) Poly(para-Phenylene Ethynylene) (PPE)- and Poly(para-Phenylene Vinylene) (PPV)-Poly[(2-(Methacryloyloxy)Ethyl) Trimethylammonium Chloride] (PMETAC) Graft Copolymers Exhibit Selective Antimicrobial Activity. European Polymer Journal, 98. pp. 368-374. ISSN 0014-3057

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    Abstract

    Antimicrobial resistance is becoming a global health concern; as such, the need for new effective treatments and preventive measures is increasing. Poly(para-phenylene ethynylene) (PPE)- and poly(para-phenylene vinylene) (PPV)-poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) graft copolymers were tested against a range of clinically and industrially relevant bacteria and results showed many of these conjugated polyelectrolytes (CPE’s) to be active. Of all of the compounds tested, PPE-g-PMETAC (low molecular weight, LMW) had greatest antimicrobial activity, especially against Enterococcus faecium, Methicillin resistant Staphylococcus aureus (MRSA), Escherichia coli and Acinetobacter baumannii.

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