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Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes

Veguillas, M, Solà, R, Fernández-Ibañez, M and Maciá, B (2016) Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes. Tetrahedron Asymmetry, 27 (14-15). pp. 643-648. ISSN 0957-4166

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Abstract

© 2016 Elsevier Ltd An efficient catalyst for the enantioselective synthesis of chiral methyl carbinols from aldehydes is presented. The system uses methyltriisopropoxytitanium as a nucleophile and a readily available binaphthyl derivative as a chiral ligand. The enantioselective methylation of both aromatic and aliphatic aldehydes proceeds with good yields and high enantioselectivities under mild conditions.

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