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Ball mill and microwave assisted synthetic routes to Fluoxetine

Solà, R, Sutcliffe, OB, Banks, CE and Maciá, B (2017) Ball mill and microwave assisted synthetic routes to Fluoxetine. Sustainable Chemistry and Pharmacy, 5. pp. 14-21. ISSN 2352-5541

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Abstract

© 2016 Elsevier B.V. Remarkable advances have been made in the development of an environmentally-friendly approach for the rapid and simple construction of the Active Pharmaceutical Ingredient (API) Fluoxetine (1). These include the use of ball milling and microwave irradiation as greener alternatives − compared to conventional heating − to provide the energy needed for the chemical transformations.

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