An expedient synthesis of oxazepino and oxazocino quinazolines

Hensbergen, AW, Mills, VR, Collins, I and Jones, AM ORCID: https://orcid.org/0000-0002-3897-5626 (2015) An expedient synthesis of oxazepino and oxazocino quinazolines. Tetrahedron Letters, 56 (46). pp. 6478-6483. ISSN 0040-4039

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Abstract

A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring closures afforded a collection of analogues. The scope of the reaction was explored in terms of cyclic and acyclic linkers, ring size and substitution pattern.