Mechanotransduction in striated muscle via focal adhesion kinase

Durieux, AC, Desplanches, D, Freyssenet, O and Flück, M (2007) Mechanotransduction in striated muscle via focal adhesion kinase. Biochemical Society Transactions, 35 (5). pp. 1312-1313. ISSN 0300-5127

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Official URL: https://doi.org/10.1042/BST0351312

Abstract

Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular control of load-dependent muscle plasticity. Thereby FAK evolves as a myocellular transducer of mechanical signals towards downstream transcript expression in myofibres. Recent advances in somatic gene therapy now allow the exploration of the functional involvement of this enzyme in mechanotransduction in intact muscle. ©The Authors.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	04 May 2010 12:33
Publisher:	Portland Press
Additional Information:	This article was originally published [following peer-review] in Biochemical Society Transactions, published by and copyright Portland Press Ltd.
Divisions:
Subject terms:	Muscle, Skeletal, Animals, Humans, Mechanotransduction, Cellular, Focal Adhesion Protein-Tyrosine Kinases, Animals, Focal Adhesion Protein-Tyrosine Kinases, Humans, Mechanotransduction, Cellular, Muscle, Skeletal, 0601 Biochemistry and Cell Biology, 1101 Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology
URI:	https://e-space.mmu.ac.uk/id/eprint/97869
DOI:	https://doi.org/10.1042/BST0351312
ISSN	0300-5127
e-ISSN	1470-8752

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