The relationship between gender and age with monocyte tissue factor expression

Scully, P., Tighe, P., Gilmore, G. A., Wallace, Julie M. W., Strain, J. J., McNulty, Helene, Ward, Mary and Gilmore, William S. (2009) The relationship between gender and age with monocyte tissue factor expression. Journal of Thrombosis and Thrombolysis, 28 (2). pp. 156-165. ISSN 1573-742X

File not available for download.

Abstract

Background In normal healthy individuals, the level of tissue factor (TF) expression on monocytes is low. However, studies have shown that patients with cardiovascular disease (CVD) have elevated levels of TF. As the risk of CVD increases with age and is more prominent in the male population, it is postulated that TF expression may be positively correlated with these factors. However, very few studies have examined the relationship between age and gender on TF expression. Methods This study evaluated the influence of age and gender on TF expression using data obtained from female (n = 44) and male (n = 27) subjects. We also examined the influence of BMI and total fat intake on TF expression in the same subjects. Results The results of our study found no significant difference in TF expression between the male and female subgroups. No correlation was found between TF and age, BMI or total fat intake in the male or female groupings. Conclusion It may be postulated that the risk of CVD development in such populations may not be due to increases in TF expression with increasing age or gender differences.