Manchester Metropolitan University's Research Repository

In vitro colonization of an experimental silicone by Candida albicans

Rodger, Gillian, Taylor, Rebecca L., Pearson, Gavin J. and Verran, Joanna (2010) In vitro colonization of an experimental silicone by Candida albicans. ISSN 1552-4981

File not available for download.


Denture soft-lining materials are exposed to the oral cavity for long periods and are in continuous contact with saliva, subject to inhibition of liquid molecules, and susceptible to colonization by microorganisms. The opportunist yeast Candida albicans is of particular concern in this context, being associated with denture plaque and denture-related stomatitis. In this study, penetration of C. albicans into an experimental silicone elastomer soft-lining material was investigated under batch and continuous culture conditions. A model denture plaque microcosm was also used. Increasing the filler concentration within the elastomer decreased penetration under both batch and continuous culture conditions. In continuous culture, C. albicans penetration was significantly greater in pure culture than in the presence of bacteria after 72-h incubation (p < 0.05).

Impact and Reach


Activity Overview
6 month trend
6 month trend

Additional statistics for this dataset are available via IRStats2.


Actions (login required)

View Item View Item