Effects of variation in exercise training load on cognitive performances and neurotrophic biomarkers in patients with coronary artery disease

Boidin, Maxime ORCID: https://orcid.org/0000-0002-1522-1223, Grégoire, Catherine-Alexandra, Gagnon, Christine, Thorin-Trescases, Nathalie, Thorin, Eric ORCID: https://orcid.org/0000-0001-5827-8935, Nigam, Anil, Juneau, Martin, Guillaume, Arthur, Tremblay, Jonathan ORCID: https://orcid.org/0000-0001-5160-0012, Gayda, Mathieu ORCID: https://orcid.org/0000-0003-1721-2299 and Bherer, Louis (2024) Effects of variation in exercise training load on cognitive performances and neurotrophic biomarkers in patients with coronary artery disease. Journal of Applied Physiology, 137 (5). pp. 1158-1167. ISSN 8750-7587

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Abstract

We used a novel and supervised iso-energetic training, integrating both moderate- and high-intensity aerobic exercises. Our findings indicate that greater variation in training load did not yield cognitive enhancements, although both protocols exhibited positive effects on brain-derived neurotrophic factor (BDNF) levels. Moreover, this study establishes a clear positive association between short-term and working memory and neurotrophic biomarkers. In addition, the independent predictive value of change in insulin-like growth factor-1 (IGF-1) on improvement in short-term and working memory highlight the close relationship between neurotrophic markers and cognition. Consequently, our results advocate for exercise training interventions targeting neurotrophic biomarkers to enhance cognitive function among individuals with coronary artery disease.