Separation and quantification of novel synthetic regioisomeric fentanyls in clinical extracts by high pH reverse-phase LC-MS/MS

Barrett, Benjamin, Euerby, Melvin, Field, Jennifer, Gilbert, Nicolas, Moreau, Stephane and Sutcliffe, Oliver B ORCID: https://orcid.org/0000-0003-3781-7754 (2024) Separation and quantification of novel synthetic regioisomeric fentanyls in clinical extracts by high pH reverse-phase LC-MS/MS. In: International Symposium of Chromatography (ISC 2024), 6 October 2024 - 10 October 2024, Liverpool, UK.

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Official URL: https://isc2024.org/

Abstract

Fluorofentanyl exists in several regioisomeric forms, all with similar LogD values and chromatography, resulting in difficulty by MS/MS analysis to confirm the regioisomeric form. A newly developed, high pH separation method demonstrating separation was used following a mini-validation according to ISO 17025 and LAB51 guidelines. Nineteen samples collected from emergency departments in Philadelphia, PA, were quantified for a panel of novel fentanyl and fluorofentanyl derivatives.

Item Type:	Conference or Workshop Item (Poster)
Peer-reviewed:	No
Date Deposited:	17 Oct 2024 10:00
Additional Information:	This is a poster presentation first given at International Symposium of Chromatography (ISC 2024)
Divisions:	Faculties > Science and Engineering Faculties > Science and Engineering > Department of Natural Sciences
URI:	https://e-space.mmu.ac.uk/id/eprint/636255

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