Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization

Gandra, UR, Sinopoli, A, Moncho, S ORCID: https://orcid.org/0000-0003-1631-5587, Nandakumar, M, Ninković, DB, Zarić, SD ORCID: https://orcid.org/0000-0002-6067-2349, Sohail, M ORCID: https://orcid.org/0000-0002-8221-818X, Al-Meer, S, Brothers, EN, Mazloum, NA, Al-Hashimi, M ORCID: https://orcid.org/0000-0001-6015-2178 and Bazzi, HS (2019) Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization. ACS Applied Materials and Interfaces, 11 (37). pp. 34376-34384. ISSN 1944-8244

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Abstract

Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.