Muscular Adaptations to Concurrent Resistance Training and High-Intensity Interval Training in Adults with Type 2 Diabetes: A Pilot Study

Orlando, Giorgio ORCID: https://orcid.org/0000-0001-6721-8248, Pugh, Jamie, Faulkner, Steve ORCID: https://orcid.org/0000-0003-4688-7252, Balducci, Stefano, Sacchetti, Massimo ORCID: https://orcid.org/0000-0002-5365-5161, Pugliese, Giuseppe, Bazzucchi, llenia ORCID: https://orcid.org/0000-0002-6017-1683, Haxhi, Jonida ORCID: https://orcid.org/0000-0003-2319-869X, Martinez-Valdes, Eduardo, Falla, Deborah ORCID: https://orcid.org/0000-0003-1689-6190, Manolopoulos, Konstantinos and Nimmo, Myra A (2023) Muscular Adaptations to Concurrent Resistance Training and High-Intensity Interval Training in Adults with Type 2 Diabetes: A Pilot Study. International Journal of Environmental Research and Public Health, 20 (18). 6746. ISSN 1661-7827

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Abstract

This pilot study aimed to compare the effects of eight weeks of concurrent resistance training (RT) and high-intensity interval training (HIIT) vs. RT alone on muscle performance, mass and quality in adults with type 2 diabetes (T2DM). Twelve T2DM adults were randomly allocated to the RT + HIIT (n = 5) or RT (n = 7) group. Before and after training, maximal oxygen uptake (VO2max), muscle strength and power were evaluated by calorimetry, dynamometry and one-repetition maximum (1RM) test. Quadriceps muscle volume was determined by MRI, and muscle quality was estimated. After RT, VO2max (+12%), knee muscle power (+20%), quadriceps muscle volume (+5.9%) and quality (leg extension, +65.4%; leg step-up, +223%) and 1RM at leg extension (+66.4%), leg step-up (+267%), lat pulldown (+60.9%) and chest press (+61.2%) significantly increased. The RT + HIIT group improved on VO2max (+27%), muscle volume (+6%), muscle power (+9%) and 1RM at lat pulldown (+47%). No other differences were detected. Among groups, changes in muscle quality at leg step-up and leg extension and VO2max were significantly different. The combination of RT and HIIT effectively improves muscle function and size and increases cardiorespiratory fitness in adults with T2DM. However, HIIT combined with RT may interfere with the development of muscle quality.