Ten-year analysis of bacterial colonisation and outcomes of major burn patients with a focus on Pseudomonas aeruginosa

Gomersall, Jenny, Mortimer, Kalani, Hassan, Deniz, Whitehead, Kathryn A ORCID: https://orcid.org/0000-0001-6001-6686, Slate, Anthony J ORCID: https://orcid.org/0000-0002-7062-6901, Ryder, Steven F, Chambers, Lucy E, El Mohtadi, Mohamed and Shokrollahi, Kayvan (2024) Ten-year analysis of bacterial colonisation and outcomes of major burn patients with a focus on Pseudomonas aeruginosa. Microorganisms, 12 (1). p. 42. ISSN 2076-2607

Preview

Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

A retrospective descriptive study included patients admitted with severe burns over the course of 10 years (2008–2018). Across all patients, there were 39 different species of bacteria, with 23 species being Gram-negative and 16 being Gram-positive bacteria, with also five different species of fungi cultured. Pseudomonas aeruginosa was the most commonly isolated organism, with 57.45% of patients having a positive culture. There was a significant difference in the number of P. aeruginosa isolated from patients that acquired their burns at work, in a garden, inside a vehicle, in a garage or in a public place. In patients that were positive for P. aeruginosa, the number of operations was higher (2.4) and the length of stay was significantly increased (80.1 days). Patients that suffered from substance abuse demonstrated significantly higher numbers of isolated P. aeruginosa (14.8%). Patients that suffered from both mental health illness and substance abuse demonstrated significantly higher numbers of P. aeruginosa isolated (18.5%). In the P. aeruginosa-negative group, there were significantly fewer patients that had been involved in a clothing fire. Furthermore, in the P. aeruginosa-negative patient cohort, the mortality rate was significantly higher (p = 0.002). Since the incidence of P. aeruginosa was also associated with a decreased mortality rate, it may be that patients admitted to hospital for shorter periods of time were less likely to be colonised with P. aeruginosa. This study demonstrates novel factors that may increase the incidence of P. aeruginosa isolated from burn patients.