Electrodes’ configuration influences the agreement between surface EMG and B-mode ultrasound detection of motor unit fasciculation

Botter, Alberto ORCID: https://orcid.org/0000-0002-4797-0667, Vieira, Taian ORCID: https://orcid.org/0000-0002-6239-7301, Carbonaro, Marco ORCID: https://orcid.org/0000-0002-0877-7960, Cerone, Giacinto L ORCID: https://orcid.org/0000-0002-5295-5314 and Hodson-Tole, Emma F ORCID: https://orcid.org/0000-0003-1200-1724 (2021) Electrodes’ configuration influences the agreement between surface EMG and B-mode ultrasound detection of motor unit fasciculation. IEEE Access, 9. pp. 98110-98120. ISSN 2169-3536

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Abstract

Muscle fasciculations, resulting from the spontaneous activation of motor neurons, may be associated with neurological disorders, and are often assessed with intramuscular electromyography (EMG). Recently, however, both ultrasound (US) imaging and multichannel surface EMG have been shown to be more sensitive to fasciculations. In this study we combined these two techniques to compare their detection sensitivity to fasciculations occurring in different muscle regions and to investigate the effect of EMG electrodes' configuration on their agreement. Monopolar surface EMGs were collected from medial gastrocnemius and soleus with an array of 32 electrodes (10 mm Inter-Electrode Distance, IED) simultaneously with b-mode US images detected alongside either proximal, central or distal electrodes groups. Fasciculation potentials (FP) were identified from single differential EMGs with 10 mm (SD1), 20 mm (SD2) and 30 mm (SD3) IEDs, and fasciculation events (FE) from US image sequences. The number, location, and size of FEs and FPs in 10 healthy participants were analyzed. Overall, the two techniques showed similar sensitivities to muscle fasciculations. US was equally sensitive to FE occurring in the proximal and distal calf regions, while the number of FP revealed by EMG increased significantly with the IED and was larger distally, where the depth of FE decreased. The agreement between the two techniques was relatively low, with a percentage of fasciculation classified as common ranging from 22% for the smallest IED to 68% for the largest IED. The relevant number of events uniquely detected by the two techniques is discussed in terms of different spatial sensitivities of EMG and US, which suggest that a combination of US-EMG is likely to maximise the sensitivity to muscle fasciculations.