Acetaminophen ingestion improves muscle activation and performance during a 3-min all-out cycling test

Morgan, P ORCID: https://orcid.org/0000-0001-7254-4507, Vanhatalo, A, Bowtell, JL, Jones, AM and Bailey, SJ (2018) Acetaminophen ingestion improves muscle activation and performance during a 3-min all-out cycling test. Applied Physiology, Nutrition and Metabolism, 44 (4). pp. 434-442. ISSN 1715-5312

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Official URL: https://cdnsciencepub.com/doi/10.1139/apnm-2018-05...

Abstract

Acute acetaminophen (ACT) ingestion has been shown to enhance cycling time-trial performance. The purpose of this study was to assess whether ACT ingestion enhances muscle activation and critical power (CP) during maximal cycling exercise. Sixteen active male participants completed two 3-min all-out tests against a fixed resistance on an electronically braked cycle ergometer 60 min after ingestion of 1gofACTorplacebo (maltodextrin, PL). CP was estimated as the mean power output over the final 30 s of the test and W= (the curvature constant of the power–duration relationship) was estimated as the work done above CP. The femoral nerve was stimulated every 30 s to measure membrane excitability (M-wave) and surface electromyography (EMG RMS ) was recorded continuously to infer muscle activation. Compared with PL, ACT ingestion increased CP (ACT: 297 ± 32 W vs. PL: 288 ± 31 W, P < 0.001) and total work done (ACT: 66.4 ± 6.5 kJ vs. PL: 65.4 ± 6.4 kJ, P = 0.03) without impacting W= (ACT: 13.1 ± 2.9 kJ vs. PL: 13.6 ± 2.4 kJ, P = 0.19) or the M-wave amplitude (P = 0.66) during the 3-min all-out cycling test. Normalised EMG RMS amplitude declined throughout the 3-min protocol in both PL and ACT conditions; however, the decline in EMG RMS amplitude was attenuated in the ACT condition, such that the EMG RMS amplitude was greater in ACT compared with PL over the last 60 s of the test (P = 0.04). These findings indicate that acute ACT ingestion might increase performance and CP during maximal cycling exercise by enhancing muscle activation.

Item Type:	Article (Article)
Peer-reviewed:	Yes
Date Deposited:	17 Nov 2023 18:11
Publisher:	Canadian Science Publishing
Additional Information:	This is an Author Accepted Manuscript of an article published in Applied Physiology, Nutrition and Metabolism, by Canadian Science Publishing.
Divisions:	Faculties > Science and Engineering Research Centres > Musculoskeletal Sciences & Sport Medicine
Subject terms:	Science & Technology, Life Sciences & Biomedicine, Nutrition & Dietetics, Physiology, Sport Sciences, analgesic, critical power, electromyography, exercise performance, muscle activation, neuromuscular fatigue, CRITICAL POWER, PERIPHERAL FATIGUE, PARACETAMOL ACETAMINOPHEN, NEUROMUSCULAR FATIGUE, METABOLIC-RESPONSES, EXERCISE, PAIN, TIME, ENDURANCE, EXCITABILITY, Muscle, Skeletal, Humans, Acetaminophen, Exercise Test, Electromyography, Cross-Over Studies, Double-Blind Method, Muscle Fatigue, Physical Endurance, Muscle Contraction, Time Factors, Bicycling, Adult, Male, Muscle Strength, Young Adult, activation musculaire, analgesic, analgésique, critical power, electromyography, exercise performance, fatigue neuromusculaire, muscle activation, neuromuscular fatigue, performance physique, puissance critique, électromyographie, Acetaminophen, Adult, Bicycling, Cross-Over Studies, Double-Blind Method, Electromyography, Exercise Test, Humans, Male, Muscle Contraction, Muscle Fatigue, Muscle Strength, Muscle, Skeletal, Physical Endurance, Time Factors, Young Adult, 06 Biological Sciences, 11 Medical and Health Sciences, Sport Sciences
URI:	https://e-space.mmu.ac.uk/id/eprint/633285
DOI:	https://doi.org/10.1139/apnm-2018-0506
ISSN	1715-5312
e-ISSN	1715-5320

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