Potential of adipose derived stem cell preparations in neurological repair and regeneration

Combes, Laura, Sawkulycz, Xenia, Fang, Wen-Hui, Guo, Baoqiang and Slevin, Mark ORCID: https://orcid.org/0000-0003-3767-4861 (2021) Potential of adipose derived stem cell preparations in neurological repair and regeneration. Biophysics Reports, 7 (2). pp. 81-90. ISSN 2364-3420

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Abstract

Stem cell therapy is a promising treatment for neurogenerative disease as well as inflammatory and immune mediated diseases. Decades of preclinical research has demonstrated stem cell ability to differ-entiate into multiple cell lineages and be utilised in regeneration and repair with their immunomodu-latory and immunosuppressive properties. This work has provided the fundamental scientific know-ledge needed to launch various clinical trials studying stem cell therapy in autoimmune disorders, stroke, and other tissue injury. Despite the early success many of these promising therapies are yet to breakthrough into clinical use. In this review, we highlight the recent developments in the use of stem cells as therapeutic agents for neurological conditions as well as their failures and how the clinical translation can be improved.