e-space
Manchester Metropolitan University's Research Repository

    Ex vivo perfusion of the human placenta to investigate pregnancy pathologies

    Zabel, Rachel R, Favaro, Rodolfo R, Groten, Tanja, Brownbill, Paul and Jones, Sarah ORCID logoORCID: https://orcid.org/0000-0001-8154-3928 (2022) Ex vivo perfusion of the human placenta to investigate pregnancy pathologies. Placenta, 130. pp. 1-8. ISSN 0143-4004

    [img]
    Preview
    Published Version
    Available under License Creative Commons Attribution.

    Download (1MB) | Preview

    Abstract

    Pregnancy pathologies including gestational diabetes, intrauterine fetal growth restriction, and pre-eclampsia are common and significantly increase the risk of poor pregnancy outcomes. Research to better understand the pathophysiology and improve diagnosis and treatment is therefore crucial. The ex vivo placenta perfusion model offers a unique system to study pregnancy pathology without the risk of harm to mother or fetus. The presence of a maternal and fetal circulation and intact villus tree, facilitates investigations into maternal-fetal transfer, altered hemodynamics and vascular reactivity in the human placenta. It also provides a platform to test novel therapeutic agents. Here we review the key studies which have utilized the ex vivo placenta perfusion model to study different aspects of such pregnancy pathologies.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    177Downloads
    6 month trend
    59Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record