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    Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro

    Santos, L, Gonçalves, LS, Bagheri-Hanei, S, Möller, GB, Sale, C ORCID logoORCID: https://orcid.org/0000-0002-5816-4169, James, RM and Artioli, GG (2021) Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro. Amino Acids, 53 (11). pp. 1763-1766. ISSN 0939-4451

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    Abstract

    We evaluated whether insulin could stimulate β-alanine uptake by skeletal muscle cells in vitro. Mouse myoblasts (C2C12) (n = 3 wells per condition) were cultured with β-alanine (350 or 700 µmol·L−1), with insulin (100 µU·mL−1) either added to the media or not. Insulin stimulated the β-alanine uptake at the lower (350 µmol·L−1) but not higher (700 µmol·L−1) β-alanine concentration in culture medium, indicating that transporter saturation might blunt the stimulatory effects of insulin.

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