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    Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro

    Santos, L, Gonçalves, LS, Bagheri-Hanei, S, Möller, GB, Sale, C ORCID logoORCID: https://orcid.org/0000-0002-5816-4169, James, RM and Artioli, GG (2021) Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro. Amino Acids, 53 (11). pp. 1763-1766. ISSN 0939-4451

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    Abstract

    We evaluated whether insulin could stimulate β-alanine uptake by skeletal muscle cells in vitro. Mouse myoblasts (C2C12) (n = 3 wells per condition) were cultured with β-alanine (350 or 700 µmol·L−1), with insulin (100 µU·mL−1) either added to the media or not. Insulin stimulated the β-alanine uptake at the lower (350 µmol·L−1) but not higher (700 µmol·L−1) β-alanine concentration in culture medium, indicating that transporter saturation might blunt the stimulatory effects of insulin.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 24 Oct 2022 12:57
    Publisher: Springer (part of Springer Nature)
    Additional Information: This is an Open Access article which appeared in Amino Acids, published by Springer
    Divisions: Faculties > Science and Engineering
    Subject terms: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, beta-alanine, Insulin, Taurine transporter, Carnosine, AMINO-ACID TRANSPORTER, CARNOSINE, TAURINE, HPAT1, Cell Line, Myoblasts, Animals, Mice, Insulin, beta-Alanine, Biological Transport, Muscle Fibers, Skeletal, Carnosine, Insulin, Taurine transporter, β-alanine, Animals, Biological Transport, Cell Line, Insulin, Mice, Muscle Fibers, Skeletal, Myoblasts, beta-Alanine, 0304 Medicinal and Biomolecular Chemistry, 1101 Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology
    URI: https://e-space.mmu.ac.uk/id/eprint/630600
    DOI: https://doi.org/10.1007/s00726-021-03090-9
    ISSN 0939-4451
    e-ISSN 1438-2199

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