Characterization of psu dic(6;5)(p21.3;q13) with reverse chromosome painting in a patient with secondary myelodysplastic syndrome following treatment for multiple myeloma

Lee-Jones, L ORCID: https://orcid.org/0000-0003-1255-3545, Ramsahoye, B, Booth, M, Thompson, P, Whittaker, J and Hoy, T (2004) Characterization of psu dic(6;5)(p21.3;q13) with reverse chromosome painting in a patient with secondary myelodysplastic syndrome following treatment for multiple myeloma. Cancer Genetics and Cytogenetics, 148 (1). pp. 49-54. ISSN 0165-4608

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Abstract

We report a case of a psu dic(6;5)(p21.3;q13) in a patient with secondary myelodysplastic syndrome (sMDS) following treatment for multiple myeloma. The abnormal chromosome was isolated by flow karyotyping and initially identified by reverse chromosome painting. The findings were then confirmed by forward painting. The value of flow karyotyping as a diagnostic technique in hematologic malignancies is discussed. © 2004 Elsevier Inc. All rights reserved.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	25 Jul 2022 10:12
Publisher:	Elsevier
Additional Information:	This is an Accepted Manuscript of an article which appeared in Cancer Genetics and Cytogenetics, published by Elsevier
Divisions:	Faculties > Science and Engineering Research Centres > Centre for Bioscience
Subject terms:	Science & Technology, Life Sciences & Biomedicine, Oncology, Genetics & Heredity, IN-SITU HYBRIDIZATION, CYTOGENETIC ANALYSIS, MARKER CHROMOSOMES, TRANSLOCATION, LEUKEMIA, PCR, IDENTIFICATION, DISORDERS, FISH, DNA, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 6, Humans, Multiple Myeloma, Myelodysplastic Syndromes, Chromosome Aberrations, In Situ Hybridization, Fluorescence, Chromosome Painting, Karyotyping, Middle Aged, Female, Chromosome Aberrations, Chromosome Painting, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 6, Female, Humans, In Situ Hybridization, Fluorescence, Karyotyping, Middle Aged, Multiple Myeloma, Myelodysplastic Syndromes, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis
URI:	https://e-space.mmu.ac.uk/id/eprint/629773
DOI:	https://doi.org/10.1016/S0165-4608(03)00218-8
ISSN	0165-4608

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