Manchester Metropolitan University's Research Repository

Studying Effects of Calcium Oxide Nanoparticles on Dentinogenesis in Male Wistar Rats

Al-Maula, Bushra Habeeb and Wally, Zena Jehad and Al-Magsoosi, Mohanad Jameel Najm and Dosh, Rasha Hatem and Mustafa, Ruba M and Al-Nasrawi, Suhad Jabbar Hamed and Alfutimie, Abdullatif and Haider, Julfikar (2021) Studying Effects of Calcium Oxide Nanoparticles on Dentinogenesis in Male Wistar Rats. International Journal of Dentistry, 2021. pp. 1-9. ISSN 1687-8728

Available under License Creative Commons Attribution.

Download (3MB)


This study aimed to evaluate potential impacts of calcium oxide nanoparticles (CaO-NPs) at different dosages on predentin thickness, number of blood vessels, periodontal ligament thickness, and blood glucose level of Wistar rats. Twelve rats were randomly gathered into four groups, untreated (control) and CaO-NP-treated groups at three concentrations (25, 50, and 100 mg/kg of the body weight) over a period of 60 days. Histological investigation was performed on twenty-four lower incisor teeth extracted from all the tested groups under a light microscope, and an automatic Fujifilm was used to measure the blood glucose level. The results showed that regular nanoparticle treatment significantly increased predentin and periodontal ligament thicknesses, a gradual decrease in vascularization in the pulp tissue, and an increase in the blood glucose level as the dosages of nanoparticles administered to the rats increased. Administration of the CaO-NPs at low dosage (25 mg/kg) could be beneficial for the growth and integrity of teeth and dentinal tissues in rats.

Impact and Reach


Activity Overview

Additional statistics for this dataset are available via IRStats2.


Actions (login required)

View Item View Item