e-space
Manchester Metropolitan University's Research Repository

Nanoscience-Led Antimicrobial Surface Engineering to Prevent Infections

Zare, Mina, Zare, Mohamad, Butler, Jonathan A and Ramakrishna, Seeram (2021) Nanoscience-Led Antimicrobial Surface Engineering to Prevent Infections. ACS Applied Nano Materials, 4. pp. 4269-4383. ISSN 2574-0970

[img]
Preview
Accepted Version
Download (2MB) | Preview

Abstract

One of the major complications associated with the implantation of biomedical devices regardless of their function is biomaterial-associated infection. Infections are generally initiated by opportunistic bacterial colonization and biofilm development on the surface of implanted biomaterials, rendering the infection impervious to host defenses and antimicrobials. Moreover, the infection around soft tissues also has a significant role in biomaterial-associated infections. It is well-documented that the nature of an implant infection is influenced by the design and composition of the implant biomaterial, host environment, clinical procedure, and patient hygiene. Herein, we explore the adhesion mechanisms of bacteria to the biomaterials and review systematic antimicrobial strategies to reduce the contamination of biomaterials and underlying implant infection using Staphylococcus aureus as a model bacterial pathogen. Also, we discuss the preventive and therapeutic strategies and explain the future perspectives for the development of nanoscience-based strategies for the engineering of antimicrobial surfaces, including the nanostructure surface, microbe–surface interactions, synthetic nanostructured surfaces, dynamic surfaces with antifouling agents, and coated surfaces with antimicrobial properties (polymer coating, surface release active coating).

Impact and Reach

Statistics

Activity Overview
6 month trend
44Downloads
6 month trend
54Hits

Additional statistics for this dataset are available via IRStats2.

Altmetric

Actions (login required)

View Item View Item