e-space
Manchester Metropolitan University's Research Repository

    Sedentary behaviour is an independent predictor of diabetic foot ulcer development: An 8-Year prospective study.

    Orlando, Giorgio, Reeves, Neil D, Boulton, Andrew JM, Ireland, Alex ORCID logoORCID: https://orcid.org/0000-0003-1094-9183, Federici, Giovanni, Federici, Adalberto, Haxhi, Jonida, Pugliese, Giuseppe and Balducci, Stefano (2021) Sedentary behaviour is an independent predictor of diabetic foot ulcer development: An 8-Year prospective study. Diabetes Research and Clinical Practice, 177. ISSN 0168-8227

    [img]
    Preview
    Published Version
    Available under License Creative Commons Attribution Non-commercial No Derivatives.

    Download (724kB) | Preview

    Abstract

    Aims To prospectively explore the association between sedentary time (SED-time) and the development of diabetic foot ulcer (DFU) in people with diabetic peripheral neuropathy (DPN). Methods 175 DPN individuals who attended the annual evaluation for the SAMBA Study (2012–2019) were included. Main outcome measure was the first diagnosis of DFU. SED-time was measured by the PAS 2.1 questionnaire. Nerve function was evaluated by nerve conduction studies. Vascular function was assessed by Ankle-brachial index (ABI) and pedal pulses. Foot deformity and skin dryness were examined by visual inspection. Results 62 participants (35.5%) developed a DFU during the study. SED-time was significantly higher in people who developed DFUs (12.8 ± 3.0 vs 9.4 ± 3.1 h/day). Logistic regression showed that among several nervous (motor amplitude, OR 0.33, 95% CI, 0.18–0.60; sensory amplitude, 0.85, 0.77–0.94) and vascular parameters (ABI, 0.23, 0.1–0.61; pedal pulses, 2.81, 0.12–0.63) and foot characteristics (deformity, 2.63, 1.30–5.32; skin dryness, 2.04, 0.95–4.37), SED-time was one of the strongest variables contributing to the development of DFUs (2.95, 1.45–6.44). Conclusions SED-time is an independent predictor of the risk of DFU in people with DPN. The monitoring of SED-time with strategies aimed at reducing it should be included in the standard care of diabetic patients.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    431Downloads
    6 month trend
    131Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record