e-space
Manchester Metropolitan University's Research Repository

    Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds

    Roberts, Dean D and McLaughlin, Mark G (2021) Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds. Organic Letters, 23 (11). pp. 4463-4467. ISSN 1523-7060

    [img]
    Preview
    Accepted Version
    Download (843kB) | Preview

    Abstract

    We describe, for the first time, a highly regioselective hydrosilylation of propargylic amines. The reaction utilizes a PtCl2/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic amines in high yields. The reaction is tolerant to a wide variety of functional groups and provides high value intermediates with two distinct functional handles. The synthetic applicability of the reaction has been shown through the synthesis of diverse ambiphilic aziridines.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    159Downloads
    6 month trend
    64Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record